Buy Tramadol from india
|Blister pack||10 pills|
|Delivery time||8 – 24 days|
|100 mg x 30 pills||60$|
|100 mg x 90 pills||100$|
|100 mg x 180 pills||150$|
Active substance group
drops for oral administration, capsules, long-acting capsules, solution for injection, solution for oral administration, rectal suppositories, pills, tablets, film-coated, sustained-release tablets
Use is contraindicated in the following cases: hypersensitivity state, accompanied by respiratory depression or severe depression of the Central nervous system (poisoning by alcohol, hypnotic drugs, narcotic analgesics and other psychoactive drugs and substances), pregnancy, lactation (in the case of prolonged use), children’s age (up to 1 year – for parenteral administration; to 14 years – oral), receiving MAO inhibitors, severe hepatic and/or renal insufficiency (KK less 10 ml/min).
Must be used with caution in addiction, confusion, intracranial hypertension, traumatic brain injury, epileptic syndrome (cerebral origin), patients on background of pain in the abdominal cavity of unknown origin.
How to apply: the dosage and course of treatment
Can be applied intravenously, intramuscularly, subcutaneously, orally, rectally.
Inside: for single use adults and children over 14 years – 0.05 mg (tablets, capsules) with a small amount of liquid or 20 drops of solution (or drops) for intake with a small amount of liquid or on sugar. 30-60 min repeat administration of the same dose, but not more than 8 doses per day.
Pill retard – 100-200 mg every 12 h Daily dose of 0.4 g (in exceptional cases, such as in cancer patients may reduce the interval to 6 hours and increase dose).
Rectal – 0.1 g. the Multiplicity of admission – up to 4 times a day.
In/in slowly, the p/to or/m: 0.05-0.1 g If the effect is insufficient, through 20-30 mines after the on/in the introduction you can continue the infusion at a rate of 12 mg HR or additionally assign inside. The total daily dose of 0.4mg.
Children under the age of 1 year – inwards only drops or parenterally (in/in, in/m, p/K), at a dose of 1-2 mg/kg Daily dose of 4-8 mg/kg (1 cap – 2.5 mg).
The elderly and patients with renal insufficiency require individual dosage (possibly lengthening T1/2). When KK less 30 ml/min and in patients with liver failure need 12 hours interval between taking regular doses of the drug.
Synthetic opioid analgesic with a Central action and the action on the spinal cord (promotes the opening of potassium and calcium channels, causing hyperpolarization activated membrane and inhibits the pain impulses conduction), increases the effects of sedative drugs. Activates Waismann receptors (mu-, Delta-, Kappa) on the pre – and postsynaptic membranes of afferent fibers of the nociceptive system in the brain and the gastrointestinal tract.
Slows down the destruction of catecholamines and stabilizes their concentration in the CNS.
Tramadol affinity to opioid receptors is 10 times weaker than that of codeineand 3000 times weaker than morphine. The intensity of analgesic action 5-10 times weaker than morphine.
Analgesic effect is due to a decrease in the activity of nociceptive and antinociceptive systems, increases the body.
In therapeutic doses the drug does not affect a meaningful way on hemodynamics and respiration, does not change the pressure in pulmonary artery, negligible slows down intestinal motility without causing constipation. Has some antitussive and sedative effect. Depresses the respiratory center, excites launcher zone of the vomiting center, the nucleus of the oculomotor nerve.
With prolonged use may develop tolerance.
Analgesic effect develops within 15-30 minutes after ingestion and lasts up to 6 hours.
From the nervous system: sweating, dizziness, headache, weakness, fatigue, lethargy, paradoxical CNS stimulation (nervousness, agitation, anxiety, tremors, muscle spasms, euphoria, emotional lability, hallucinations), sleepiness, sleep disturbance, confusion, violation of coordination of movements, seizures of Central origin (at/in the introduction in high doses or with concomitant administration of antipsychotic drugs (neuroleptics), depression, amnesia, impaired cognitive function, paresthesias, unsteady gait.
From the digestive system: dry mouth, nausea, vomiting, flatulence, abdominal pain, constipation or diarrhea, difficulty in swallowing.
Of the cardiovascular system manifestations of vasodilation – tachycardia, orthostatic hypotension, syncope, collapse.
Allergic reactions when using the drug: hives, itching, rash, bullous rash.
From the urinary system: difficulty urinating, dysuria, urinary retention.
From the senses: blurred vision, taste.
The respiratory system: dyspnoea.
Other: violation of the menstrual cycle.
Long-term use develop drug dependence. When abrupt cancellation – syndrome “cancel”.
Symptoms: miosis, vomiting, collapse, coma, convulsions, depression of respiratory center, sleep apnea.
For the treatment of overdose it is necessary to secure the airway, maintain breathing and the activity of the cardiovascular system. Aviatophobia effects can be relieved by naloxone, convulsions – benzodiazepines.
Not used for the treatment of the syndrome “lifting” of drugs.
Should not simultaneously use ethanol.
In the case of a single reception there is no need to stop breast feeding.
During the period of treatment must be careful when driving and occupation of other potentially hazardous activities, require high concentration and psychomotor speed reactions.
The preparation is pharmaceutically incompatible with solutions of diclofenac, indomethacin, of phenylbutazone, diazepam, flunitrazepam, nitroglycerin.
Enhances the effect of drugs, CNS depressants, and ethanol.
Inducers of microsomal oxidation (including carbamazepine, barbiturates) reduce the severity of the analgesic effect and duration of action of the drug.
Prolonged use of opioid analgesics or barbiturates stimulate the development of cross-tolerance.
Anxiolytics increase the intensity of the analgesic effect; increasing duration of anesthesia in combination with barbiturates.
Naloxone activates breath eliminating analgesia after use of opioid analgesics.
MAO inhibitors, furazolidone, procarbazine, antipsychotic drugs (neuroleptics) increase the risk of seizures (decrease seizure threshold).
Quinidine increases the plasma concentration of tramadol and M1 metabolite reduces due to competitive inhibition of isoenzyme CYP2D6.